SQSTM1 anticorps (pSer272, pThr269)

N° du produit ABIN6655165

N° du produit (Fournisseur): 600-401-x19

L’anticorps Lapin Polyclonal anti-SQSTM1 a été validé pour WB et ELISA. Il convient pour détecter SQSTM1 dans des échantillons de Humain.

Aperçu rapide pour SQSTM1 anticorps (pSer272, pThr269) (ABIN6655165)

Antigène: SQSTM1 (Sequestosome 1 (SQSTM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SQSTM1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SQSTM1 anticorps

Épitope: pSer272, pThr269

N° du produit (Fournisseur): 600-401-x19

Fournisseur: Rockland

Fonction: p62 Phospho T269/Ser272 Antibody

Réactivité croisée (Details): Anti-Phospho-Thr269/Ser272 p62 Antibody is directed against p62 protein phosphorylated at T269 and S272.

Purification: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Stérilité: Sterile filtered

Immunogène: Anti-Phospho-Thr269/Ser272 p62 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Thr269/Ser272 of human p62 conjugated to KLH.

Isotype: IgG

Information d'application

Indications d'application:

ELISA_Dilution: 1:10,000

Western_Blot_Dilution: 1:1000

Commentaires:

Anti-Phospho-Thr269/Ser272 p62 Antibody is tested for Western Blots and is specific for the ~62 kDa p62 protein phosphorylated at Thr269 and Ser272. Specific conditions for reactivity should be optimized by the end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Preservative: None

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Date de péremption: 12 months

Détails sur SQSTM1

Antigène: SQSTM1 (Sequestosome 1 (SQSTM1))

Autre désignation: SQSTM1

Sujet:

Synonyms: Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, p60, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62

Background: p62, also known as sequestosome1 (SQSTM1), is a shuttle protein transporting polyubiquitinated proteins for both proteasomal and lysosomal degradation. p62 is an integral component of inclusions in brains of various neurodegenerative disorders, including Alzheimer disease (AD) neurofibrillary tangles (NFTs) and Lewy bodies in Parkinson disease. p62 plays an important role in the protection of cells from the toxicity of misfolded proteins by enhancing aggregate formation especially in the later stages. Phosphorylation of Ser28 has recently been demonstrated to be related to the pathogenesis of Parkinson's disease. p62 pT269/pS272 Antibody is ideal for researchers interested in neuroscience research.

Gene Name: SQSTM1

ID gène: 8878

NCBI Accession: NP_003891

UniProt: Q13501

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy